| 国产乙型肝炎疫苗不同剂量免疫效果的研究 |
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| 引用本文： | 李雪翔 邬嘉生. 国产乙型肝炎疫苗不同剂量免疫效果的研究[J]. 现代免疫学, 1990, 10(1): 20-23 |
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| 作者姓名： | 李雪翔 邬嘉生 |
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| 作者单位： | 卫生部上海生物制品研究所(李雪翔，肖亮明，江圣寅，方锡玲，谢广中)，上海市卢湾区卫生防疫站(邬嘉生)，上海市长宁区卫生防疫站(钱婉华)，上海铁路局中心防疫站(廖秋萍)，山东省临沂地区卫生防疫站(王佐沂)，山东省莒南县卫生防疫站(刘德堂)，卫生部上海生物制品研究所(孙景明) |
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| 摘 要： | 本文报道应用上海生物制品研究所生产的乙型肝炎(血源)疫苗对上海、山东8～11岁的血清乙肝标志均阴性的学龄儿童,随机分至5μg、10μg和 20μg三组,按0、1、6月免疫程序接种,全程后 3月(即首针后 9月)三组的 Anti-HBs阳转率分别为 94.4％、99.1％和 90.4％。GMT(几何均数滴度)RIA S/N 在107.1～140.6之间;24月时阳转率仍在90.9～96.5％之间,S/N 在89.1～118.8之间。S/N≥10 者5μg、10μg和 20μg各为 90.0％、94.0％和 86.4％,无显著性差异。
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| 关 键 词： | 乙肝疫苗 剂量 免疫效果 |
TITERS AND PERSISTENCE OE ANTIBODIES FOLLOWING VACCINATION WITH DIFFERENT DOSES OF HEPATITIS B VACCINE IN CHILDREN |
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| Abstract: | Children 8-11 year old were screened with RIA for markers of hepatitis B virus infection (HBsAg, Anti-HBs, Anti-HBc) and negative ones entered into the test program. They were randomly divided into three groups, receiving 5μg,10μg and 20μg hepatitis B vaccine recpectively for three doses at o, 1 and 6 months. Nine months after the first dose, antibody to hepatitis B surface antigen (Anti-HBs) was detected by radioimmunoassay. No difference in the three groups was observed on the serocon-version rate (Tab 1. p>0.05) . Twenty-four months after the start of the vaccination programme,over 90% of subjects remained positive for Anti-HBS. The geometric mean titer (GMT) in RIA S/N units were between. 94.2-121.5. In the three groups, those with GMT S/N≥10 were 90.0%, 94% and 86.4% respectvely. These results demonstrated that three doses of 5μg of hepatitis B vaccine were sufficient in children to obtain a high immunogenic effect. |
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