| 草酸钾溶液(250g/L)急性毒理、皮肤刺激实验的研究 |
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| 引用本文： | 张广耘,徐秦.草酸钾溶液(250g/L)急性毒理、皮肤刺激实验的研究[J].实用口腔医学杂志,2002,18(2):146-147. |
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| 作者姓名： | 张广耘 徐秦 |
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| 作者单位： | 1. 青岛医学院附属青岛市立医院口腔科266011
2. 新疆医科大学预防医学院 |
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| 摘 要： | 目的：为临床安全应用草酸钾溶液（250g/L）治疗牙本质敏感症提供基础根据。方法：采用昆明小鼠和大白兔分别进行了急性毒理和急性皮肤刺激实验。结果：该浓度的草酸钾溶液未影响雌雄小鼠的生长情况，皮肤未出现红斑和水肿，动物生长状态良好。结论：250g/L草酸钾溶液作为临床局部用药完全、无毒。
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| 关 键 词： | 草酸钾 急性毒性试验 皮肤试验 牙本质敏感症 治疗 |
| 文章编号： | 1001-3733(2002)-02-0146-02 |
| 修稿时间： | 2001年9月12日 |
Acute toxicity and acute skin stimulation of 250 g/L potassium oxalate solution |
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| Abstract: | ?Objective:To study the toxicity of 250 g/L potassium oxalate solution.Methods:Acute toxicity test and acute skin stimulation test were carried out on Kunmin mice and rabbits.Results:Potassium oxalate solution at 250 g/L did not result in death of the mice even it had been administered at the dose of 10 000 mg/kg by stomach filling.The LD 50 was more than 5 475 mg/kg.The solution did not cause skin reaction in rabbits after application.Conclusion:250 g/L potassium oxalate solution is not toxic and not stimulative as a local applied drug. |
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| Keywords: | Potassium oxalate Acute toxic test Skin test |
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