Synthesis and dopamine receptor binding of bridged tricyclic dopamine analogues |
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| Institution: | 1. Institute of Nanoscience and Nanotechnology, National Center for Scientific Research “Demokritos”, Aghia Paraskevi 15341, Attiki, Greece;2. Institute of Biosciences & Applications, National Center for Scientific Research “Demokritos”, Aghia Paraskevi 15341, Attiki, Greece;3. University of Lyon, CNRS, UMR 5223, IMP, UCBL, 15 bd André Latarjet, F-69622 Villeurbanne, France;4. Laboratory of Bioinorganic Chemistry, Department of Chemistry, University of Crete, Voutes Campus, 70013 Heraklion, Crete, Greece;5. Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital - Radium Hospital, 0379 Oslo, Norway |
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| Abstract: | The bridged tricyclic dopamine analogues exo-2-(N-n-propylamino)-6,7-dihydroxybenzonorbornene, exo-2-(N,N-di-n-propylamino)-6,7-dihydroxybenzonorbornene, and exo-2-amino-6,7-dihydroxybenzobicyclo2.2.2]octene have been synthesized and assayed for their effects on the binding of 3H]spiperone and 3H]apomorphine to rat striatal membranes. The inactivity of these compounds is rationalized on the basis of proposed topographical models of dopamine receptors. |
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