Genetics of two human monocyte antigens |
| |
Affiliation: | 1. From the Department of Immunohaematology and Blood Bank, University Hospital, Leiden, The Netherlands;2. Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands;1. Cancer Metabolism Research Unit, Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK |
| |
Abstract: | HMA-1 and HMA-2 are two serologically defined alloantigens that are present on human monocytes and granulocytes. Previous panel studies suggested that these two antigens comprise a diallelic system. We therefore performed segregation studies on 10 randomly chosen families and on 22 nucleus families belonging to one large pedigree. All individuals were either positive for HMA-1, HMA-2, or both. Segregation of HMA-1 showed autosomal inheritance with complete penetrance. The cytotoxicity negative, absorption positive (CYNAP) phenomenon sometimes occurred for HMA-2, and because absorptions for HMA-2 could not be performed on all cells, linkage studies were only performed for HMA-1. No linkage of HMA-1 with HLA, immunoglobulin allotypes, granulocyte antigens, or any of the erythrocyte blood groups tested was observed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|