Therapeutic potential of silymarin as a natural iron‐chelating agent in β‐thalassemia intermedia |
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| Authors: | Nahid Reisi Nafiseh Esmaeil Marjan Gharagozloo Behjat Moayedi |
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| Institution: | 1. Department of Pediatric Hematology and Oncology, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan Iran ; 2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan Iran ; 3. Department of Neurology, Johns Hopkins Medicine, Baltimore Maryland, USA |
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| Abstract: | Abnormal iron accumulation in vital organs is one of the major complications of β‐thalassemia intermedia (β‐TI). Silymarin, a flavonolignan isolated from Silybum marianum, significantly decreases the serum ferritin levels of β‐TI patients. This finding suggests silymarin as a safe and effective natural iron‐chelating agent for the treatment of iron‐overloaded conditions. |
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| Keywords: | ferritin iron chelator liver milk thistle silymarin thalassemia |
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