多发性硬化患者中枢灰质损伤与临床症状的相关性研究进展

一般来说，多发性硬化（MS）的病理改变以中枢白质病变为主，然而，由于MS患者出现的认知功能障碍等临床表现无法完全用白质病变来解释，因此MS患者中枢灰质损伤日益受到重视。高场强磁共振成像技术（MRI）的发展使得能在患者出现临床症状的同时清晰地观察其灰质病变，但患者临床症状与中枢灰质（特别是皮质）病变之间的相关性仍需深入研究。因此，本文将对MS疾病进程中患者中枢灰质损伤与临床症状（主要包括认知障碍和癫痫等）的关系做一综述。

Correlation between grey matter damage and clinical symptom of multiple sclerosis:research advances

Generally,the pathological changes of multiple sclerosis(MS) is mostly on lesion of the central white matter (WM). However,the clinical symptoms such as cognitive impairment cannot be fully explained just by the WM damage. Therefore, central gray matter(GM)damage has attracted more attention. The development of magnetic resonance imaging(MRI)makes in vivo detection of GM while showing the clinical symptoms possible. Yet,the correlation between the patient clinical symptoms and GM dam?age particularly in cortex still need to be elucidated. Hence,we summarize the historical background and give an overview of the corre?lation between GM damage and MS clinical symptoms in terms of cognitive impairment and epilepsy.