| 正交设计结合Box-Behnken效应面法优选银桑菊固体饮料提取工艺 |
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| 引用本文： | 李跃辉,王银,彭宇,何亚辉,杨再江,向丽. 正交设计结合Box-Behnken效应面法优选银桑菊固体饮料提取工艺[J]. 国际药学研究杂志, 2016, 0(4): 761-767. DOI: 10.13220/j.cnki.jipr.2016.04.034 |
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| 作者姓名： | 李跃辉 王银 彭宇 何亚辉 杨再江 向丽 |
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| 作者单位： | 1. 湖南省中医药研究院杨永华名老中医药专家传承工作室, 长沙,410006;2. 重庆市秀山红星中药材开发有限公司, 重庆,409900 |
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| 基金项目： | 重庆市科技支持项目(cstc2014fqzktjcsf10019) |
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| 摘 要： | 目的：优选银桑菊固体饮料（YSJ）的提取工艺。方法以绿原酸、多糖含量和浸膏得率的总评“归一值”（OD）为评价指标，通过正交设计初步优选YSJ的提取工艺，Box-Behnken效应面法进一步优化其工艺。结果正交设计优选的最佳工艺为：加10倍量水，浸泡0.5 h，提取2次，每次1.5 h；Box-Behnken效应面法优选的工艺为：加10.82倍水，浸泡0.51 h，提取2次，每次1.77 h。结论经实验结果对比可知，Box-Behnken效应面法优选的提取工艺参数更精确，更细致且预测性好，产品质量提高。
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| 关 键 词： | 银桑菊固体饮料 正交设计 Box-Behnken效应面法 总评“归一值”(OD) 绿原酸 多糖 浸膏得率 |
Extraction optimization for Yinsangju solid beverage by orthogonal design and Box-Behnken design-response surface methodology |
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| LI Yue-hui;WANG Yin;PENG Yu;HE Ya-hui;YANG Zai-jiang;XIANG Li. Extraction optimization for Yinsangju solid beverage by orthogonal design and Box-Behnken design-response surface methodology[J]. Foreign Medical Sciences(Section of Pharmarcy), 2016, 0(4): 761-767. DOI: 10.13220/j.cnki.jipr.2016.04.034 |
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| Authors: | LI Yue-hui WANG Yin PENG Yu HE Ya-hui YANG Zai-jiang XIANG Li |
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| Affiliation: | LI Yue-hui;WANG Yin;PENG Yu;HE Ya-hui;YANG Zai-jiang;XIANG Li;Hunan TCM Academy Yang Yonghua Inheritance Studio of the Famous TCIYI Experts;Chongqing Xiushan Hongxing Traditional Chinese Meteria Medica Development Co.Ltd.; |
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| Abstract: | Objective To optimize extraction process of Yinsangju solid beverage(YSJ). Methods The extraction of YSJ was preliminarie optimized through the orthogonal design,and then further optimized by Box-Behnken design-response surface with the overall desirability(OD)of chlorogenic acid and polysaccharide content and yield of extract as evaluation indexes. Results The op?timum extraction of orthogonal design was as follow:10 times the amount of water,soaked 0.5 h,extracted 2 times,each time 1.5 h. The optimum extraction of Box-Behnken design was 10.82 times the amount of water,soaked 0.51 h,extracted 2 times,each time 1.77 h. Conclusion The test results show that the Box-Behnken response surface method optimization of extraction process parameters is more precise and more detailed and predictability is good,and the product quality is improved. |
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| Keywords: | Yinsangju solid beverage orthogonal design Box-Behnken design-response surface methodology overall desir-ability chlorogenic acid polysaccharide yield of extract |
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