以白藜芦醇为分子骨架的活性衍生物研究进展

天然产物白藜芦醇具有抗氧化、心血管保护等多种有益的生物活性，近年来吸引了越来越多科研工作者的关注；但其成药性差，不能直接作为药物开发。对白藜芦醇的分子结构进行化学修饰可得到具有更优良成药性的衍生物。研究表明，白藜芦醇衍生物具有多种确切的生物活性，包括抗肿瘤、降血脂、抗病毒、抗神经退行性疾病等多种重要的作用，可作为新的活性药物先导物。本文对近年来白藜芦醇的化学修饰研究进展做系统综述。

Active derivatives based on the resveratrol scaffold:research advances

Natural product resveratrol has antioxidation,cardiovascular protection and many other useful biological activities. In recent years,many researchers have paid more and more attention to it. However it cannot be used as candidate for the development of new drug due to its poor druggability. Novel resveratrol derivates with improved water solubility and highly potent biological activity could be obtained by chemical modifying of chemical structure of resveratrol. Researches have shown that resveratrol derivatives exhib?it many kinds of attractive activities,including antitumor,reducing blood fat,antiviral,anti-neurodegenerative diseases and so on, which makes them could be used as leads for the further developing of new drugs. This review discusses the development of novel resve?ratrol derivatives by chemical modification in recent years..