Aldose reductase and advanced glycation endproducts inhibitory effect of Phyllostachys nigra |
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Authors: | Jung Sang Hoon Lee Jung Min Lee Hee Ju Kim Chul Young Lee Eun Ha Um Byung Hun |
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Affiliation: | Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute, Gangneung 210-340, Korea. |
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Abstract: | To evaluate active principles for diabetic complications from the black bamboo leaves, Phyllostachys nigra, eight compounds were isolated and tested for their effects on rat lens aldose reductase and advanced glycation endproducts. As a result, luteolin 6-C-(6'-O-trans-caffeoylglucoside) was found to show a strong aldose reductase and advanced glycation endproducts inhibition. This compound showed antioxidative activity measured in Photochem apparatus. It is concluded, therefore, that luteolin 6-C-(6'-O-trans-caffeoylglucoside) (6), a flavone of this plant, have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, this compound could be offered as a leading compound for further study as a new natural products drug for diabetic complications. |
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