| 羟基喜树碱对H22肝癌模型小鼠药效学的研究 |
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| 引用本文： | 胡巍,张尚锁,方芸. 羟基喜树碱对H22肝癌模型小鼠药效学的研究[J]. 现代中药研究与实践, 2011, 0(2): 40-43 |
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| 作者姓名： | 胡巍 张尚锁 方芸 |
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| 作者单位： | 南京大学医学院附属鼓楼医院;南京中医药大学; |
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| 基金项目： | 南京市卫生局医学科技发展课题(项目编号YKK08052) |
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| 摘 要： | 目的 考察羟基喜树碱(HCPT)对小鼠H22模型的抗肿瘤作用.方法 以小鼠H22肝癌模型为实验观察对象.观察HCPT对肿瘤的抑制效果、化疗前后的体重、食物摄取量及生长状况,同时观察HCPT对H22肝癌模型小鼠肝肾功能的保护作用.结果 阳性药对照组及HCPT高、中、低剂量化疗组对小鼠H22肝癌模型均有抑制作用(P<0.0...
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| 关 键 词： | 羟基喜树碱 药效学 肿瘤组织 酯/盐比值 |
Pharmacodynamics Study of Hydroxycamptothecin on Mice Models of H22 |
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| HU Wei,ZHANG Shang-suo,FANG Yun. Pharmacodynamics Study of Hydroxycamptothecin on Mice Models of H22[J]. Research and Practice on Chinese Medicines, 2011, 0(2): 40-43 |
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| Authors: | HU Wei ZHANG Shang-suo FANG Yun |
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| Affiliation: | HU Wei1,ZHANG Shang-suo2,FANG Yun1(1.The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China,2.Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China) |
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| Abstract: | Objective To investigate the anti-tumor effects of HCPT on the mice models of H22.Methods The mice models of H22 is the experimental observation of the object.Observing inhibitory effect of HCPT on the tumor,weight changes,growth status before and after chemotherapy.Results Positive drug group and HCPT high,medium and low-dose chemotherapy group all inhibit the mice models of H22(P<0.05),inhibition rate are 66.12%,60.26%,50.16%,30.94%,respectively.To compare with the model group,the mice living conditions(w... |
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| Keywords: | HCPT pharmacodynamics tumor tissue ester / salt ratio |
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