不同年龄段健康儿童心肌酶谱参考值的调查及分析

目的探究儿童三个年龄段心肌酶谱参考值范围及不同地域间的差异。方法对143名健康儿童采集静脉血，用速率法测定血清中的天门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、α-羟丁酸脱氢酶（α-HBDH）、肌酸激酶（CK）、肌酸激酶同功酶（CK—MB）含量，并对结果按年龄段进行统计学分析。结果①各年龄组血清中AST、LDH、α—HBDH、CK、CK-MB含量均较成人高，年龄越小，含量越高，随着年龄的增长逐渐接近成人；②三个年龄段的指标测值对比，差异具有统计学意义（P〈0．01）；③与苏州比较：婴幼儿组LDH、CK-MB（0．01〉P〉0．005，P〈0．001）；学龄前组LDH、α-HBDH、CK—MB为（P〈0．001），CK（0．05〉P〉0．02）；学龄组LDH、CK（0．02〉P〉0．01），CK-MB（P〈0．001）均具有统计学意义。结论在诊断心肌病时宜参考本地区儿童心肌酶谱的正常值。

The investigation of myocardial enzymes reference value in healthy children of different age groups

Objective To explore the reference value range of the serum myocardial enzymes of three age groups children and the differences between different regions.Methods The contents of aspartate aminotransferase (AST), lactate dehydrogenase (LDH),α-hydroxybutyrate dehydrogenase (α-HBDH) , creatine kinase(CK) , and creatine kinase mb(CK-MB) in peripheral venous blood of 143 healthy children were measured with rate method, and the results were statistically analyzed according to the age groups.Results ①The contents of AST, LDH,α-HBDH, CK, CK-MB in blood serum of all three age groups healthy children were higher than those of adults, and it was found that the younger the children, the higher the contents, which decreased with the increase of the children's age.②The indexes of measured values in three age groups had statistically significant difference(P＜0.01＝.③To compare with the children in Suzhou,it was found that the contents of LDH, CKMB in infant group(0.01＞P ＞0.005 ,P＜0.001＝ ,the contents of LDH,α-HBDH,CK-MB(P＜0.001＝ ,especially CK (0.05＞P＞0.02) in preschool children group,and the contents of LDH,CK(0.02＞P＞0.01), CK-MB (P＜0.001＝ in school group children had statistically significant differences.Conclusion The children' s myocardial enzymes values in this area should be taken into reference in the diagnosis of myocardiopathy.