| 老年人心肌细胞自噬的变化及其调控机制研究进展 |
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| 引用本文： | 杨利国,赵惠萍,李保,秦富忠. 老年人心肌细胞自噬的变化及其调控机制研究进展[J]. 中华老年医学杂志, 2021, 0(2): 265-268 |
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| 作者姓名： | 杨利国 赵惠萍 李保 秦富忠 |
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| 作者单位： | 山西医科大学第二医院心血管内科 |
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| 基金项目： | 国家自然科学基金(81470526、81670369、81870214)。 |
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| 摘 要： | 心肌细胞自噬对维持正常心脏结构和功能起重要作用。近年来的研究结果表明老年人心肌细胞自噬功能降低,老年人心肌自噬基因Atg5、Atg7和Beclin1表达降低;心肌细胞自噬下调与磷脂酰肌醇3-激酶/丝氨酸-苏氨酸激酶/雷帕霉素靶蛋白和单磷酸腺苷激活的蛋白激酶及SIRT1信号通路失调有关;此外,活性氧及一些神经内分泌因子也可介导老年人心肌细胞自噬下调。调控心肌细胞自噬将为老年人心肌病的预防和治疗提供新的途径。
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| 关 键 词： | 自噬 肌细胞,心脏 细胞衰老 |
Advances in research on altered cardiomyocyte autophagy and its regulatory mechanisms in the elderly |
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| Yang Liguo,Zhao Huiping,Li Bao,Qin Fuzhong. Advances in research on altered cardiomyocyte autophagy and its regulatory mechanisms in the elderly[J]. Chinese Journal of Geriatrics, 2021, 0(2): 265-268 |
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| Authors: | Yang Liguo Zhao Huiping Li Bao Qin Fuzhong |
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| Affiliation: | (Department of Cardiovascular Medicine,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Cardiomyocyte autophagy plays an important role in maintaining normal cardiac structure and function.Recent studies have shown that cardiomyocyte autophagy is decreased in the aging heart.The expression of autophagy-related genes Atg5,Atg7 and Beclin1 decreases in the aging myocardium.Decreased cardiomyocyte autophagy in the aging heart is associated with dysregulation of phosphatidylinositol-3-kinase(PI3K)/serine-threonine kinase(Akt)/mammalian target of rapamycin(mTOR),adenosine monophosphate-activated protein kinase(AMPK)and/or the SIRT1 signaling pathways.In addition,reactive oxygen species and some neural hormonal factors such as endothelin-1 can also mediate the decrease of cardiomyocyte autophagy in cardiac aging.The regulation of cardiomyocyte autophagy may provide new strategies for the prevention and treatment of cardiomyopathy in the elderly. |
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| Keywords: | Autophagy Myocardial,cardiac Cell aging |
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