维生素C联合碳酸氢钠对早期糖尿病肾病患者经皮冠状动脉介入治疗时造影剂肾病的预防效果

目的分析维生素C联合碳酸氢钠对早期糖尿病肾病患者经皮冠状动脉介入治疗(PCI)时造影剂肾病的预防效果。方法选取2017年5月至2019年7月在厦门大学附属第一医院行PCI的82例早期糖尿病肾病患者,根据治疗方式的不同分为两组,各41例。对照组采用常规水化法,试验组在对照组基础上采用维生素C联合碳酸氢钠治疗,比较两组造影前后的肌酐清除率(CCr)、血尿素氮(BUN)和血清肌酐(SCr)水平及造影剂肾病发生情况。结果造影后3 d,试验组CCr高于对照组,BUN和SCr水平低于对照组,差异均有统计学意义(P<0.05);试验组造影剂肾病发生率低于对照组,差异有统计学意义(P<0.05)。结论维生素C联合碳酸氢钠对早期糖尿病肾病患者PCI时造影剂肾病的预防效果较好。

Effect of Vitamin C Combined with Sodium Bicarbonate on the Prevention of PCI Contrast Agent Nephropathy in Patients with Early Diabetic Nephropathy

Objective To analyze the preventive effect of vitamin C combined with sodium bicarbonate on PCI contrast agent nephropathy in patients with early diabetic nephropathy.Methods A total of 82 patients with early diabetic nephropathy who underwent PCI in the First Affiliated Hospital of Xiamen University from May 2017 to July 2019 were selected,and divided into two groups according to the different methods of treatment,41 cases each.The control group using conventional hydration,on this basis,the experimental group was treated with vitamin C in combination with sodium bicarbonate,compared the two groups before and after angiography in patients with creatinine clearance rate(CCr),blood urea nitrogen(BUN)and serum creatinine(SCr)levels,as well as the contrast nephropathy is happening.Results Three days after angiography,the level of CCr in the control group was lower than that in the experimental group(P<0.05),and the level of BUN and SCr in the control group were higher than that in the experimental group(P<0.05).The incidence of contrast nephropathy in the control group was higher than that in the experimental group(P<0.05).Conclusion The application of vitamin C combined with sodium bicarbonate hydration in PCI in early diabetic nephropathy can effectively prevent contrast agent nephropathy.