中国65岁及以上老年人睡眠时长与认知功能受损的关联研究

目的探索我国65岁及以上老年人每日睡眠时长与认知功能受损之间的关联。方法数据来自中国老年健康影响因素跟踪调查在2017-2018年调查的数据集,最终共纳入14966名研究对象,同时收集社会经济状况、社会参与、行为、饮食营养、生活习惯、家庭结构、疾病状况、心理健康、认知功能等数据。用简易精神状态评价量表(MMSE)评价老年人的认知功能。采用广义线性混合效应模型分析睡眠时长与认知功能受损之间的关联,并进一步分析不同年龄组(65~79岁、80~89岁、90~99岁和≥100岁)、性别研究对象睡眠时长和认知功能受损间的关联。结果14966名研究对象中,65~79岁、80~89岁、90~99岁和≥100岁的研究对象分别有5148名(34.40%)、3777名(25.24%)、3322名(22.20%)和2719名(18.16%);女性有8455名(56.49%);每日睡眠时长≤5 h和≥9 h的老年人分别有2704名(18.94%)和3883名(27.19%);认知功能受损者有3748名(25.04%)。广义线性混合效应模型的结果显示,与自报每日睡眠时长为7 h者相比,睡眠时长≤5 h和睡眠时长≥9 h与认知功能受损有关联,OR值(95%CI)分别为1.35(1.09~1.68)和1.70(1.39~2.07)。分层分析的结果显示,睡眠时长与认知功能受损之间的关联在65~79岁老年人和男性老年人中更为显著。结论老年人睡眠时长过短或过长可增加认知功能受损的发生风险。

Association of sleep duration with cognitive impairment among older adults aged 65 years and older in China

Objective The study is to examine association of sleep duration and cognitive impairment in the older adults aged 65 years and older in China.Methods We analyzed data from 2017-2018 wave of Chinese Longitudinal Healthy Longevity Survey(CLHLS).A total of 14966 participants were included in the analysis.Data with respect to socioeconomic status,community involvement,behavior pattern,diet,life style,family structure,disease condition,mental health and cognitive function were collected.Cognitive function was measured with Mini-mental State Examination(MMSE).We conducted generalized linear mixed models to examine associations of sleep duration with cognitive impairment,and subgroup analyses of sex and age were conducted.Results Among 14966 participants,the percentage of participants aged 65 to 79 years,80 to 89 years,90 to 99 years and 100 years and older was 5148(4.40%),3777(25.24%),3322(22.20%)and 2719(18.16%),respectively.A total of 2704 participants reported sleep duration of 5 h and less,and 3883 reported 9 h and more,accounting for 18.94%and 27.19%,respectively.In total,3748 were defined with cognitive impairment,accounting for 25.04%.The results of generalized linear mixed models showed that both short(≤5 h)and long(≥9 h)sleep duration were associated with cognitive impairment compared with sleep duration of 7 h,with OR(95%CI)of 1.35(1.09-1.68)and 1.70(1.39-2.07),respectively.The association of sleep duration with cognitive impairment was more obvious in males and individuals aged 65 to 79 years old.Conclusion Short or long sleep duration was responsible for increased risk of cognitive impairment in older Chinese.