序列位置效应联合延迟回忆识别不同认知障碍水平患者的研究

目的 探索序列位置效应联合延迟回忆在区分不同认知障碍水平人群的诊断价值.方法 共纳入310例受试,其中认知正常(NC)组128例,轻度认知功能障碍(MCI)组133例,轻度阿尔茨海默病(AD)组49例.3组性别、年龄、受教育程度无显著性差异.所有受试进行成套神经心理学测验,使用听觉词语学习测验量表华山版(AVLT-H)...

A study on the value of the serial position effect combined with delayed recall of auditory verbal learning test in distinguishing elderly patients with different levels of cognitive impairment

Objective To explore the diagnostic value of the serial position effect combined with delayed recall of auditory verbal learning test in diagnosing the elderly patients with different levels of cognitive impairment.Methods A total of 310 subjects were enrolled and divided into three groups:the normal control group(NC group,n=128),the mild cognitive impairment group(MCI group,n=133)and the mild Alzheimer's disease group(mild AD group,n=149)matched for gender,age and education level.Comprehensive neuro-psychological tests were performed on all subjects,and the Auditory Verbal Learning Test-Huashan version(AVLT-H)was used to analyze the serial position effect.Results There were significant differences in the primacy effect of the second and third time of immediate recall,short-term and long-term delayed recall among the three groups(P<0.05),but no difference was found in the recency effect between the MCI and mild AD groups(P>0.05).The long-term delayed primacy effect combined with the short-term delayed recall showed a better validity to distinguish those elderly subjects with different levels of cognitive impairment than other memorial indexes,and the correlative sensitivity and specificity were 83.21%and 71.43%(NC group vs.MCI group),85.71%and 92.86%(NC group vs.mild AD group),66.67%and 75.57%(MCI group vs.mild AD group),respectively.Conclusions The long-term delayed primacy effect combined with the short-term delayed recall can assist in distinguishing elderly patients with different levels of cognitive impairment.