| Leptin RIA在急性脑梗死患者中的临床意义 |
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| 引用本文： | 张慧玲,陈永生. Leptin RIA在急性脑梗死患者中的临床意义[J]. 放射免疫学杂志, 2005, 18(6): 454-455 |
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| 作者姓名： | 张慧玲 陈永生 |
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| 作者单位： | 山东省临沂市人民医院,276003;山东省临沂市人民医院,276003 |
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| 摘 要： | 目的:通过对79例急性脑梗死患者血清瘦素(leptin)水平的检测,探讨脑梗死与瘦素的关系及发生机制。方法:患者79例(男48,女31),年龄(36~80)岁。均经CT证实。入院后第2d抽取空腹静脉血,用放射免疫分析(R IA),检测血清瘦素,同时检测56例健康成人作对照组。结果:脑梗死组瘦素水平显著高于对照组(t=3.99,P<0.01)。轻、重症患者无差异。结论:急性脑梗死患者存在高瘦素血症和瘦素抵抗,瘦素参与了能量平衡的调节,瘦素水平增高是急性脑梗死的危险标志物。其发生机理有待深入研究。
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| 关 键 词： | 瘦素 脑梗死 |
| 收稿时间： | 2005-04-14 |
| 修稿时间： | 2005-04-14 |
Clinical Significance of the Changes of Serum Leptin Levels in Patients with Acute Cerebral Infarction |
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| Zhang Huiling,Chen Yongsheng. Clinical Significance of the Changes of Serum Leptin Levels in Patients with Acute Cerebral Infarction[J]. Journal of Radioimmanology, 2005, 18(6): 454-455 |
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| Authors: | Zhang Huiling Chen Yongsheng |
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| Abstract: | Objective To study the relationship between cerebral infaction and changes of serum leptin and to explore the occurrence mechanism of cerebral infarction.Methods Serum leptin(with RIA) levels were measured in 79 patients with CT proved cerebral infarction and 56 controls.Results The serum leptin levels in patients with cerebral infarction were significantly higher than those in the controls (t=3.99,P<0.01),with no difference between the levels in mild and severe patients.Conclusion There are hyperleptinemia and leptin resistance in cerebral infarction patients.Leptin takes part in regulation of energy equilibrum.Increase of leptin level is a risk marker for cerebral infarction and further study on the mechanism in needed. |
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| Keywords: | leptin cerebral infarction |
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