| 脑脉舒宁对大鼠主动脉条收缩的影响 |
| |
| 引用本文： | 王淑英 王建刚. 脑脉舒宁对大鼠主动脉条收缩的影响[J]. 河南医学研究, 1999, 8(1): 11-12 |
| |
| 作者姓名： | 王淑英 王建刚 |
| |
| 作者单位： | 洛阳医学高等专科学校药理教研室 |
| |
| 摘 要： | 目的：探讨脑脉舒宁降压作用的机理。方法：采用大鼠胸主动脉条测定脑脉舒宁对去甲肾上腺素（ＮＥ）、ＣａＣｌ２的量效曲线以及对单剂量氯化钾所致收缩的影响。结果：脑脉舒宁能使ＮＥ、ＣａＣｌ２的量效曲线右移，最大反应压低，呈非竞争性拮抗；同时也可抑制高钾去极化引起的血管条收缩。结论：脑脉舒宁松弛血管平滑肌的作用与拮抗Ｃａ２＋有关。
|
| 关 键 词： | 胸主动脉条；去甲肾上腺素；氯化钙；氯化钾；脑脉舒宁 |
Effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium |
| |
| Wang Shuying Wang Jiangang Li Yan et al. Effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium[J]. Henan Medical Research, 1999, 8(1): 11-12 |
| |
| Authors: | Wang Shuying Wang Jiangang Li Yan et al |
| |
| Abstract: | Objective: To explore the mechanism blood lowering effect of Naomaishuning.Methods: The effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium.Results: The results showed that Naomaishuning shifted the cumulative concentration response curves for CaCl 2 and norepinephrine to right,and depressed their maximal responses.It appeared that the Naomaishuning was noncompetitive antagonist to CaCl 2 and norepinephrine,Naomaishuning also inhibited the contration of aortic strips evoked by single dose of KCl.Conclusion:The results suggested that Naomaishuning block calcium channels. |
| |
| Keywords: | aortic strip calcium norepinephine potassium Naomaishuning |
| 本文献已被 CNKI 维普 等数据库收录！ |
