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Pathophysiology and management of inherited bone marrow failure syndromes |
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| Authors: | Akiko Shimamura Blanche P. Alter |
| Affiliation: | 1. Pediatric Hematology/Oncology, Fred Hutchinson Cancer Research Center and Seattle Children''s Hospital, Seattle, WA, USA;2. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA |
| Abstract: | The inherited marrow failure syndromes are a diverse set of genetic disorders characterized by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly variable and much broader than previously recognized. The medical management of the inherited marrow failure syndromes differs from that of acquired aplastic anemia or malignancies arising in the general population. Diagnostic workup, molecular pathogenesis, and clinical treatment are reviewed. |
| Keywords: | Aplastic anemia Fanconi Dyskeratosis congenita Diamond&ndash Blackfan anemia Shwachman&ndash Diamond syndrome Inherited bone marrow failure syndromes |
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