Maternal dietary substrates and human fetal biophysical activity. I. The effects of tryptophan and glucose on fetal breathing movements |
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Authors: | L D Devoe R A Castillo N S Searle J R Searle |
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Affiliation: | 1. Mersin State Hospital, Department of Obstetrics and Gynecology, Mersin, Turkey;2. Tepecik Education and Research Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey;3. Bakirkoy Sadi Konuk Research and Training Hospital, Department of Gynecology and Oncology, Istanbul, Turkey;4. Tepecik Education and Research Hospital, Department of Gynecologic Oncology, Izmir, Turkey;5. Muğla Sitki Koçman University Education and Research Hospital, Department of Gynecology and Oncology, Muğla, Turkey |
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Abstract: | To study the effects of L-tryptophan and glucose on fetal breathing activity, we examined 40 women with normal term pregnancies, randomly assigned to four equal groups who either continued fasting (group C), received 1 gm of oral tryptophan (group T), received 100 gm of oral glucose (group G), or received both substrates (group T + G). Studies lasted 210 minutes, during which fetal breathing movements were observed with real-time ultrasonography and entered and analyzed for incidence, rate, and variability on a microcomputer. Plasma glucose and tryptophan levels were determined every 30 minutes. The incidence of fetal breathing movements declined in group C and rose significantly in the other groups. Breathing rates were unchanged in groups C and T but rose significantly in groups G and T + G during peak breathing intervals. Breath interval variability did not change significantly in any study group. Maternal administration of tryptophan is associated with an alteration in fetal breathing activity but to a lesser degree than that observed after maternal glucose loading. |
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