The urinary output of d- and l-amphetamine in man |
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| Authors: | L M Gunne |
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| Affiliation: | 1. Faculty of Chemistry, Department of Analytical Chemistry, Hanoi University of Science, Vietnam National University, 19 Le Thanh Tong, Hanoi, Viet Nam;2. Center of Drugs Expertise, Institute of Forensic Science, Ministry of Public Security, 99 Nguyen Tuan, Hanoi, Viet Nam;3. National Institute for Food Control (NIFC), 13 Phan Huy Chu, Hanoi, Viet Nam;4. Department of Chemistry, University of Basel, Spitalstrasse 51, 4056 Basel, Switzerland;5. University Institute of Research in Police Sciences (IUICP), University of Alcalá, Ctra. Madrid, Barcelona Km 33.6, 28871 Alcalá de Henares (Madrid), Spain;6. Centre for Environmental Technology and Sustainable Development (CETASD), Hanoi University of Science, Nguyen Trai Street 334, Hanoi, Viet Nam |
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| Abstract: | Racemic amphetamine or methylamphetamine was administered to four human subjects, and the urine was collected in a total of fourteen experiments. The proportion of the optical isomers present in the urine was determined by gas chromatography of the diastereosiomers formed when a urine extract was reacted with trifluoroacetyl-l-prolyl chloride. After administration of racemic amphetamine the optical isomers were not excreted at the same rate. The ratio of the d-isomer to the l-isomer in the urine decreased from 0.99 during the first 12 hr to 0.46 at 48–60 hr.Although the total urinary excretion of amphetamine is pH-dependent, the differential excretion of the d- and l-isomers occurred whether the urine was acid or alkaline.Racemic methylamphetamine was metabolized to amphetamine and the main isomer excreted in the urine was d-amphetamine, whereas l-amphetamine was formed to a lesser extent. |
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