四逆汤对离体蛙心收缩性能的影响

目的:研究不同制法及不同剂量的四逆汤对离体蛙心收缩功能的影响。方法:采用离体器官实验法和改进的斯氏蛙心插管法,用不同浓度的水煎四逆汤、水煎醇沉四逆汤对离体蛙心进行心脏灌流,记录蛙心的收缩张力及收缩振幅的变化。结果:水煎生附子、水煎醇沉生附子四逆汤在低浓度时对离体蛙心有兴奋作用,高浓度则为抑制作用;而水煎制附子及水煎醇沉制附子四逆汤各剂量均呈现抑制作用;四逆汤经醇沉处理后,对离体蛙心的抑制作用减弱。结论:四逆汤对离体蛙心的作用因其醇沉处理及附子的不同炮制而异。

The Influence of Sini Decoction on Contracting Function of Isolated Toad Heart

Objective: To study the influence of Sini decoction at different doses and with different preparing methods on the contracting function of the isolated toad heart.Methods: The improved toad heart-intubation method were adopted,the isolated toad hearts were perfused Sini water decoction(SWD) or Sini water-decocted and alcohol-sinked liquid(SWDASL) at different doses,the contraction tension and the contraction extent of isolated toad heart were recorded.Results: The raw Fuzi SWD and SWDASL at the low doses had the excitation effect on isolated toad heart,while at high doses had the restraint effect on isolated toad heart;the fried Fuzi SWD and SWDASL at different doses had the restraint effect on isolated toad heart.The restraint effect on isolated toad heart was weakened,after Sini decoction was treated as alcohol-sinked liquid.Conclusion: The influence of Sini decoction on the isolated toad heart were different according to the alcohol-sinked treatment and the Fuzi with different processing.