急性脑梗死患者治疗前后血浆Hcy和血清GST检测的临床意义

目的：探讨了急性脑梗死患者治疗前后血浆Hey和血清谷胱甘肽-S-转移酶（GST）水平的变化及意义。方法：应用RIA检测血浆Hey水平，酶联免疫分析检测血清GST水平，对32例急性脑梗死患者进行了Hey和GST测定，并与35名正常健康人作比较。结果：在治疗前血浆Hey水平非常显著地高于正常人组（P〈0．01），而血清GST水平非常显著地低于正常人组（P〈0．01），经3个月治疗后，血浆Hey水平和血清GST水平与正常人比较仍有显著性差异（P〈0．05），血浆Hey水平与GST水平呈明显负相关（r=-0．4125，P〈0．05）。结论：检测急性脑梗死患者血浆Hey和血清GST水平的变化对了解病情、观察预后均有重要的临床价值。

Clinical Significance of Measurement of Plasma Hcy and Serum GST Levels After Treatment in Patients with Cerebral Infarction

Objective To exeplore the clinical significance of changes of plasma Hcy and serum GST levels after treatment in patients with cerebral infarction. Methods Plasma Hcy (with RIA) and serum GST (with ELISA) levels were determined in 32 patients with cerebral infarction both before and after treatment as well as in 35 controls. Results Before treatment, the plasma Hcy levels were significantly higher than those in controls (P<0.01), while serum GST levels were significantly lower than those in controls (P<0.01). After treatment for three months the levels, though corrected markedly, remained significantly different from those in controls (P<0.05). Plasma Hcy levels were negatively correlated with serum GST levels (r=-0.4125, P<0.05). Conclusion The plasma Hcy and serum GST levels were closely related to the diseases process of acute cerebral infarction and were of great clinical importance.