Vesicular glutamate transporters VGLUT1 and VGLUT2 in the developing mouse barrel cortex |
| |
Authors: | M. Liguz-Lecznar J. Skangiel-Kramska |
| |
Affiliation: | Laboratory of Molecular Basis of Brain Plasticity, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland. |
| |
Abstract: | Three vesicular glutamate transporters have been identified in mammals. Two of them, VGLUT1 and VGLUT2, define the glutamatergic phenotype and their distribution in the brain is almost complementary. In the present study we examined the distribution and expression levels of these two VGLUTs during postnatal development of the mouse barrel cortex. We also investigated changes in the localization of VGLUT1 and VGLUT2 within particular compartments of the barrel field (barrels/septa) during its development. We found differences in the time course of developmental expression, with VGLUT1 peaking around P14, while VGLUT2 increased gradually until adulthood. Over the examined period (P3 - adult) both transporters had stronger expression in the barrel interiors, and in this compartment VGLUT2 dominated, whereas in the inter-barrel septa VGLUT1 dominated over VGLUT2. Furthermore, we found that some nerve terminals in the barrel cortex coexpressed both transporters until adulthood. Colocalization was observed within the barrels, but not within the septa. |
| |
Keywords: | VGLUT1 VGLUT2 Barrel cortex Postnatal development |
本文献已被 ScienceDirect 等数据库收录! |
|