布地奈德鼻内雾化吸入辅助治疗急性鼻-鼻窦炎

 目的】观察布地奈德以鼻内雾化吸入的方式辅助治疗急性鼻-鼻窦炎的临床疗效。【方法】将42例急性鼻-鼻窦炎患者随机分为两组,第1组给口服头孢克洛（750mg/次,每天2次）、10g/L麻黄素滴鼻（每天3次,每次2～3滴）及鼻内布地奈德雾化吸入（每天1次,每次1mg即2mL）治疗;第2组给口服头孢克洛（750mg/次,每天2次）及10g/L麻黄素滴鼻（每天3次,每次2～3滴）,疗程共10d;治疗前后对头痛、脓涕、鼻塞、后鼻滴漏和嗅觉障碍等症状和体征进行分级评估并比较两组疗效。【结果】治疗后,第1组总有效率为90.5%,第2组总有效率为85.7%,两组比较差异无统计学意义（P〉0.05）。两组临床表现分级评分均明显下降,使用布地奈德鼻内雾化吸入组头痛、鼻塞、后鼻滴漏症状及鼻黏膜肿胀改善方面明显高于对照组（P〈0.05）。没有观察到不良反应。【结论】使用布地奈德鼻内雾化吸入对于治疗急性鼻-鼻窦炎有良好的辅助作用,且副作用不明显。

Intranasal Budesonide Nebulization as an Adjunct to Oral Antibiotic Therapy for Acute Sinusitis

Objective] To observe the clinical efficacy of intranasal nebulized budesonide inhalation in 42 cases of acute sinusitis. Method] 42 patients were randomly divided into two groups: Group 1 received 10 g/L ephedrine, oral cefaclor and intranasal budesonide for 10 days; Group 2 received 10 g/L ephedrine and cefaclor for 10 days. Symptoms such as headache, nasal stuffiness and signs of nasal discharge were graded before and after treatment. The results of the two treatment groups were compared. Result] The recovery rate of Group 1 was 90.5% and that of Group 2 was 85.7%. There was no significant difference between the two groups (P > 0.05). The scores of grading symptoms were obviously declined after treatment in both groups. In the group with intranasal budesonide, the improvement of headache, nasal stuffiness, postnasal discharge and swelling of nasal mucosa was more significant than that of control group (P < 0.05). No adverse drug effects were observed during the study period. Conclusion] These findings suggest that topical steroids may be a useful adjunctive agent in the treatment of acute sinusitis without apparent side effects and can possibly hasten the resolution of symptoms.