鲍曼不动杆菌对β-内酰胺类抗生素耐药机制的研究进展

鲍曼不动杆菌是一种不发酵葡萄糖的革兰阴性球杆菌,近年来临床检出率呈上升趋势,是医院内感染中分离的重要病原菌.鲍曼不动杆菌由于其生存力强、耐药谱广及耐药率高的特点引起了广泛地关注.其耐药机制主要包括产生β-内酰胺酶、青霉素结合蛋白改变、外膜通透性降低和主动外排增强.该文对鲍曼不动杆菌耐β-内酰胺类抗生素机制,尤其是对外膜孔蛋白和主动外排系统机制进行了详细综述.

Research progress of mechanisms of Acinetobacter baumannii resistance to β-lactam antibiotics

Acinetobacter baumannii, a glucose-nonfermentative gram-negative coccobacillus, is an important pathogen isolated in nosocomial infections, and the clinical detection rate has been increasing in recent years. Acinetobacter baumannii attracts widespread attention due to strong viability, broad resistance spectrum and high rate of drug resistance. The resistance mechanisms include the production of β-lactamases, alterations in penicillin-binding proteins, decreased outer membrane permeability and overexpression of active efflux pumps. The mechanisms of Acinetobacter baumannii resistance to β-lactam antibiotics, especially those of the outer membrane porin and active efflux system are reviewed in this paper.