Sterilitätsbehandlung durch homologe intrauterine Insemination

Homologous intrauterine insemination (IUI) both in spontaneous and, preferably, in ovulation induction cycles, is widely recommended as the first choice of assisted conception techniques. However, there is no consensus on the effectiveness of such an approach. Especially in cases of male subfertility divergent views exist with regard to the therapeutic benefit. The literature survey presented is intended to provide information on the pregnancy rates achievable after homologous IUI for male-factor subfertility. For the sake of clarity, this review is limited to prospective, randomized IUI studies conducted since 1984, which clearly indicated that the work focused on male subfertility only as well as on either spontaneous cycles or cycles stimulated with a single regimen (clomiphene citrate or gonadotropins). We conclude from evidence-based data that IUI is justified as a reasonable first-line therapy in moderate male factor cases, especially if gonadotropins are used for mild ovarian stimulation.