Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease |
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| Authors: | C M Yates J Simpson A Gordon |
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| Affiliation: | 1. State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing 100875, China;2. Institute for Energy, Environment and Sustainable Communities, University of Regina, 120, 2 Research Drive, Regina, Saskatchewan S4S 7H9, Canada;3. Beijing Engineering Research Center for Watershed Environmental Restoration & Integrated Ecological Regulation, School of Environment, Beijing Normal University, Beijing 100875, China;4. College of Water Resources and Civil Engineering, China Agricultural University, 100085, China;1. Department of Clinical Psychology and Psychobiology & Institute of Neurosciences, University of Barcelona, Barcelona, Spain;2. Department of Neuroscience and Center for Affective Sciences, University of Geneva, Geneva, Switzerland |
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| Abstract: | 5-Hydroxytryptamine (5-HT) and choline acetyltransferase (ChAT) were assayed in amygdala, cingulate cortex and caudate nucleus of post-mortem brains from 7 cases of Down's syndrome (6 with the neuropathological features of Alzheimer's disease and one with no such features), 9 cases of Alzheimer's disease and 12 controls. 5-HT was markedly reduced in all 3 areas of the pathologically affected Down brains, unaltered in the Down brain with no Alzheimer pathology and reduced in the amygdala and cingulate cortex of the Alzheimer brains. ChAT showed a similar pattern of reduction. These results supply biochemical evidence that 5-hydroxytryptaminergic, as well as cholinergic, neurons are reduced in Down's syndrome with Alzheimer pathology. |
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