Acanthamoeba infection in a patient with chronic graft‐versus‐host disease occurring during treatment with voriconazole |
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| Authors: | D.R. Kaul L. Lowe G.S. Visvesvara S. Farmen Y.A. Khaled G.A. Yanik |
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| Affiliation: | 1. Department of Internal Medicine, Division of Infectious Diseases and University of Michigan Medical School, Ann Arbor, Michigan, USA,;2. Department of Pathology and Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA,;3. Division of Parasitology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA,;4. Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA;5. Blood and Bone Marrow Transplant Program, University of Michigan Medical School, Ann Arbor, Michigan, USA |
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| Abstract: | Abstract: We report a case of disseminated infection with Acanthamoeba in a patient with graft‐versus‐host disease after hematopoietic stem cell transplant (HSCT) for acute lymphocytic leukemia. The infection involved the brain, skin, and lungs and occurred despite treatment with voriconazole for mold prophylaxis, and did not respond to treatment with multiple other agents reported to have activity against Acanthamoeba. To our knowledge, infection with Acanthamoeba has been reported in 4 other patients after HSCT or bone marrow transplant, and our case is the first to be diagnosed ante‐mortem. |
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| Keywords: | Acanthamoeba protozoa graft‐versus‐host disease voriconazole |
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