Possible impact of inflammatory status on C‐telopeptide pyridinoline cross‐links of Type I collagen and osteocalcin levels around oral implants with peri‐implantitis: a controlled clinical trial

Summary Detection of progression level of peri‐implantitis may help in the prevention of oral implant failure. C‐telopeptide pyridinoline crosslinks of Type I collagen (ICTP) and osteocalcin (OC) are specific markers of bone turnover and bone degradation. Determination of the ICTP and OC levels in the peri‐implant sulcus fluid (PISF) may predict the metabolic and/or inflammatory changes in the peri‐implant bone. The aim of this clinical study was to evaluate ICTP and OC levels in the PISF for oral implants with and without peri‐implant bone destruction and correlate these levels with the traditional clinical peri‐implant parameters (probing depth, plaque index, gingival index and gingival bleeding time index) and radiographic bone level measurements. Fifteen patients with 30 peri‐implant sites with bone destruction (radiographic bone loss) and health were included. Clinical parameters were measured and PISF was collected from the sites. Peri‐implant sulcus fluid ICTP and OC levels were detected by radioimmunoassay technique from PISF samples. All clinical parameters demonstrated a significant increase in peri‐implantitis sites compared with healthy sites. The PISF volume of the peri‐implantitis sites was also significantly higher than of the healthy peri‐implant sites. Although not statistically significant, a trend of increase was demonstrated in ICTP PISF samples sampled from peri‐implantitis sites compared with healthy sites. A significant increase was noticed for OC PISF level in peri‐implantitis sites compared with healthy ones. As well as peri‐implant clinical measurements, volumetric changes at PISF may be counted as an important clinical parameter to distinguish the bone destruction sites from healthy sites around oral implants.