| Synthesis of 3-Nitrogen-containing Function Substituted Lanosterol Derivatives-Inhibitors of (S)-Adenosyl-L-Me-thionine: Δ~(24(25))-Sterol Methyltransferase |
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| 引用本文： | 果德安,胡军,郑俊华,ＳａｍｉｒＡＲｏｓｓ,ＷＤａｖｉｄＮｅｓ. Synthesis of 3-Nitrogen-containing Function Substituted Lanosterol Derivatives-Inhibitors of (S)-Adenosyl-L-Me-thionine: Δ~(24(25))-Sterol Methyltransferase[J]. 中国药学, 1997, 0(3) |
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| 作者姓名： | 果德安 胡军 郑俊华 ＳａｍｉｒＡＲｏｓｓ ＷＤａｖｉｄＮｅｓ |
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| 作者单位： | 沈阳药科大学药学系药化教研室，沈阳药科大学合成药物研究室 |
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| 摘 要： | 本文设计合成了１０个未见文献报道的２—对甲氧基苯亚甲基５取代胺甲基环戊酮衍生物，均经红外光谱、核磁共振谱及元素分析，证实其化学结构。采用角叉菜胶诱发的大鼠足爪肿胀模型进行抗炎活性的初步筛选。在化学合成中还证实：Ｍａｎｎｉｃｈ碱的胺交换反应是消除加成反应。
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| 关 键 词： | 环戊酮衍生物；抗炎活性；胺交换反应 |
Synthesis and Antiinflammatory Activity of 2 (4 Methoxy benzylidene) 5 aminomethyl Cyclopentanone Derivatives |
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| Ying Kang ,Yu Lan Li ,Ying Xu and Zhi Zhong Ji. Synthesis and Antiinflammatory Activity of 2 (4 Methoxy benzylidene) 5 aminomethyl Cyclopentanone Derivatives[J]. Journal of Chinese Pharmaceutical Sciences, 1997, 0(3) |
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| Authors: | Ying Kang Yu Lan Li Ying Xu Zhi Zhong Ji |
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| Affiliation: | Ying Kang 1,Yu Lan Li 2,Ying Xu 1 and Zhi Zhong Ji 21 Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015, 2 Laboratory of Synthetic Drugs,Shenyang Pharmaceutical University,Shenyang 110015 |
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| Abstract: | In this paper, ten new derivatives of 2 (4 methoxybenzylidene) 5 aminomethyl cyclopentanone were designed and synthesized The structures of all these ten title compounds have been confirmed by IR, 1 H NMR and elemental analysis The compounds have been examined for the antiinflammatory activity on carrageenin induced rat paw edema test Through chemical synthesis, we have confirmed that the amino exchange reaction proceeds by an elimination addition mechanism |
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| Keywords: | Cyclopentanones Antiinflammatory activity Amino exchange reaction |
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