伊班膦酸钠联合化疗治疗骨转移瘤的临床观察

目的观察伊班膦酸钠联合化疗治疗骨转移瘤的临床效果。方法80例患者分为2组，即联合治疗组（伊班膦酸钠＋化疗）和化疗组，伊班膦酸钠4mg＋生理盐水500ml静滴，至少2h以上，每4周重复1次，化疗每3-4周重复1个周期，治疗2个周期后评价治疗效果。结果联合治疗组止痛、活动能力的改善及骨转移病灶的有效率分别为82．5％、62．5％、45％，均优于单纯化疗组（P〈0．05）。结论伊班膦酸钠联合化疗治疗骨转移瘤疗效好，毒副作用可以耐受。

Therapeutic effect of ibandronate combined with chemotherapy on bone metastasis

Objective To evaluate the efficacy of combined therapy of ibandronate and chemotherapy for cancer patients with bone metastasis.Methods All 80 patients with bone metastasis received ibandronate combined with chemotherapy or chemotherapy alone.The intravenous infusion of 4 mg ibandronate was repeated every 4 weeks.Chemotherapy was administered every 3 or 4 weeks.The therapeutic efficacy was evaluated after 2 circles of chemotherapy.Results The response rate of pain relief,improving activity of daily living and managing bone metastasis focus was 82.5%,62.5%,45% respectively in ibandronate combined with chemotherapy, and 52.5%,40%,22.5% in chemotherapy,with significant difference between the 2 therapies(P<0.05).Conclusion Combined therapy of ibandronate and chemotherapy is effective in treating cancer patients with bone metastasis and is well tolerated.