| 大鼠烟碱依赖戒断的类吗啡戒断综合征模型的建立及机制探讨 |
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| 引用本文： | 徐江平,刘传缋.大鼠烟碱依赖戒断的类吗啡戒断综合征模型的建立及机制探讨[J].军事医学科学院院刊,1996(3). |
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| 作者姓名： | 徐江平 刘传缋 |
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| 作者单位： | 军事医学科学院毒物药物研究所 |
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| 摘 要： | 大鼠连续９ｄ递增皮下注射烟碱后产生依赖，皮下注射阿片受体拮抗剂纳洛酮（４ｍｇ·ｋｇ－１）可使烟碱依赖大鼠产生明显的戒断症状，并与美加明激发的戒断症状十分相似。烟碱０．５ｍｇ·ｋｇ－１（ｓｃ）和吗啡１ｍｇ·ｋｇ－１（ｓｃ）可交叉替代缓解美加明和纳洛酮激发依赖大鼠的戒断症状。这些结果进一步证实大鼠烟碱依赖－戒断涉及阿片机制
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| 关 键 词： | 烟碱 麻醉剂依赖性 戒断 阿片 |
A model of nicotine abstinence and its mechanism of quasi morphine abstinent syndromes in rats |
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| Xu Jiangping,Liu Chuangui Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing.A model of nicotine abstinence and its mechanism of quasi morphine abstinent syndromes in rats[J].Bulletin of the Academy of Military Medical Sciences,1996(3). |
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| Authors: | Xu Jiangping Liu Chuangui Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Beijing |
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| Institution: | Xu Jiangping,Liu Chuangui Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850 |
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