菩人丹对2型糖尿病大血管损伤大鼠FFAs及血脂4项的影响

目的:探讨菩人丹(PRD)超微粉对2型糖尿病大鼠脂质代谢的调节作用。方法:采用灌胃脂肪乳结合尾静脉快速注射小剂量链脲佐菌素,建立T2DM合并大血管病变的动物模型。成模大鼠随机分为菩人丹低、中、高剂量组,马来酸罗格列酮组以及模型组,各组分别给予相应药物治疗4周,4周末杀检动物,检测血清FFAs、TC、TG、LDL-c、HDL-c含量。结果:模型大鼠血清FFAs、TC、TG、LDL-c含量较正常组明显升高(P0.01),HDL-c有下降趋势,但无统计学意义(P0.05)。PRD低剂量组及马来酸罗格列酮组均能显著降低T2DM模型大鼠TC、TG、LDL-c含量(P0.05),PRD中、高剂量均能极显著降低大鼠TC、TG、LDL-c含量(P0.01);PRD高剂量组能显著降低T2DM模型大鼠血清FFAs(P0.05),PRD中剂量组及马来酸罗格列酮组均能极显著降低T2DM模型大鼠血清FFAs(P0.01)。结论:PRD具有改善T2DM大血管损伤大鼠异常的脂质代谢作用。

Effects of Puren Dan on FFAs and four blood lipid items in large blood vessel injury rats with type 2 diabetes

Abstract Objective: To investigate the regulation effects of PRD on lipid metabolism.Method: the T2DM with macroangiopathy model of rats(Wistar,male) were induced by gavage fat emulsion combining with intravenous injection of streptozotocin(STZ,30mg/kg) through the tail.The succeed model rats were randomly divided into five groups: PRD high-dosage group,PRD middle-dosage group,PRD low-dosage group,Rosiglitazone Maleate group and model group.Each group were administering intragastrically with corresponding drugs for 4 weeks.The animals were sacrificed and serum was collected.The levels of FFAs,TC,TG,LDL-c,and HDL-c in serum were detected by automatic biochemical analyzer.Results: Compared with the control group,the levels of FFAs,TC,TG,LDL-c were increased significantly(P<0.01) in model group.After treatment with PRD,the levels of FFA,TC,TG,LDL-c were decreased(P<0.01~0.05).Conclusion: PRD has an improvement effect on disturbance of lipid metabolism in T2DM rats with macroangiopathy.