Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression. |
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Authors: | Peter Zwanzger Robin Ella Martin E Keck Rainer Rupprecht Frank Padberg |
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Affiliation: | Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany. |
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Abstract: | BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has been suggested as a potentially useful treatment for major depression. Nonpsychotic depressed patients appear to have a better outcome than those with psychotic symptoms. METHODS: We report findings in a patient suffering from recurrent, nonpsychotic major depression (DSM-IV) who had 13 daily sessions of rTMS monotherapy within a 3 week period. RESULTS: During rTMS treatment, the patient developed recurrent severe delusions, which he had never experienced before. Psychotic symptoms remitted quickly with neuroleptic medication. CONCLUSIONS: In light of preclinical findings showing increased dopaminergic activity after rTMS treatment, occurrence of psychotic symptoms should be considered a potential side effect of rTMS treatment. |
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Keywords: | rTMS depression dopamine delusions psychotic symptoms |
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