Angiotropic lymphoma with endocrine involvement |
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Authors: | J.H. SHANKS,M. HARRIS,A.J. HOWAT,& A.J. FREEMONT |
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Affiliation: | Department of Histopathology, Christie Hospital, Manchester,;Department of Histopathology, Royal Preston Hospital, Preston,;University Department of Histopathology, Manchester Royal Infirmary, Clinical Sciences Building, Manchester, UK |
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Abstract: | Aims : Two cases of angiotropic high-grade B-cell lymphoma are described in which involvement of endocrine glands was a prominent feature. Methods and results : One patient had marked unilateral adrenomegaly due to lymphoma within adrenal blood vessels. He is alive 5 years after presentation following combination chemotherapy. The diagnosis was made at autopsy in the second patient who presented with pyrexia of unknown origin and had hypothyroidism and a thyroid nodule. The thyroid gland and pituitary showed striking involvement by angiotropic lymphoma and the thyroid nodule was a cavernous haemangioma heavily colonized by lymphoma cells. Conclusions : Our cases illustrate endocrine organ manifestations of this rare disease. The condition may respond to combination chemotherapy. |
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Keywords: | angiotropic lymphoma cavernous haemangioma thyroid gland adrenal gland pituitary gland |
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