浅表性膀胱尿路上皮癌TUR-Bt术后膀胱灌注吡柔比星及丝裂霉素疗效及安全性比较

目的 比较吡柔比星与丝裂霉素膀胱灌注预防浅表性膀胱尿路上皮癌TUR-Bt术后的效疗与安全性.方法 将47例浅表性膀胱尿路上皮癌TUR-Bt术后的患者,随机分成2组,分别用吡柔比星和丝裂霉素作膀胱灌注,定期复查膀胱镜及血常规、尿常规、肝肾功能检查,观察其治疗效果及副作用.结果 吡柔比星组2例(8.7%)复发,丝裂霉素组4例(16.7%)复发,复发率吡柔比星组明显低于丝裂霉素组(P<0.05);膀胱刺激症,吡柔比星组2例(8.7%),丝裂霉素组3例(12.5%);其他副作用方面吡柔比星出现排尿困难1例.结论 丝裂霉素及吡柔比星膀胱灌注安全性相似,与丝裂霉素相比,吡柔比星具有膀胱内化疗药保留时间短、疗效高等优点.

Comparison the effect and safety of pirarubicin and mitomycin by bladder instillation for preventing postoperative recurrence on the superficial bladder urothelial carcinoma after TUR-Bt

Objective To compare the effect and safety of pirarubicin （THP） and mitomycin （MMC） by bladder instillation after transurethral resection of superficial bladder urothelial carcinoma.Methods Fourty seven patients of superficial bladder urothelial carcinoma after transurethral resection were randomly divided into two groups to receive intravesical instillation of THP or MMC,respectively.Periodical cystoscopy and blood, urine, liver and kidney function tests were performed in all, observe the efficacy and side effects.Results The tumor recurrent rate in THP group and MMC group were（8.7%）and（16.7%）,respectively.The tumor recurrent rate of THP group differed significantly from the MMC group（P〈0.05）. The recurrent rate of the bladder irritation in THP group and MMC group were（8.7%）and（12.5%）,respectively.The recurrent rate of the bladder irritation of THP group differed significantly from the MMC group（P〈0.05）.and there was 1 case of pirarubicin dysuria in THP.Conclusion Intravesical administration of THP after operation was mole effective than MMC,which had the merit of short duration,shorter period of treatmeat,and more convenience for preventing tumor recurrence.