中药对小儿反复呼吸道感染免疫干预的研究

目的:探讨中药对小儿反复呼吸道感染的免疫干预影响。方法:随机分为观察组和对照组,观察组采用中药,2次/天口服。对照组用口服卡慢舒,<4岁,每次3 mL;4~7岁,每次5 mL;>7岁,每次7 mL。每日3次。两组疗程均为8周。治疗前后两组测定血IL-12,TNF-α,IL-6,IL-13,IL-2,IL-4的变化并进行分析。结果:中药治疗后患儿的IL-12,IL-2的含量比治疗前升高。而TNF-α,IL-13,IL-4,IL-6的含量比治疗前降低。与对照组同期比较P<0.01,观察组治疗前比较P<0.01。随访1年,观察组临床呼吸道感染年均次数明显减少,与对照组比差异有显著性(P<0.01)。结论:中药能有效干预儿童反复呼吸道感染,增强儿童的抗病能力。

Effects of immunotherapy with infantile recurrent respiratory tract infection by Chinese materia medica

OBJECTIVE: To explore the effect of Chinese materia medica on immune intervention of infantile recurrent respiratory tract infection. METHOD: Thirty-one children of recurrent respiratory tract infection were randomly divided into two groups: therapy group was treated with oral Chinese materia medica (b. i. d), control group was only treated with oral carboxymethyl liquor (< 4 years, 3 mL; 4-7 years, 5 mL; > 7 years, 7 mL, t. i. d). The change of IL-12,TNF-alpha, IL-6, IL-13, IL-6 and IL-4 in different time were observed and analyzes. RESULT: Compared with the control group, the level of IL-12 and IL-2 was significantly increased after treatment of oral Chinese materia medica (P < 0.01), however, the level of TNF-alpha, IL-13, IL-4, and IL-6 was decreased after treatment (P < 0.01). During one years follow-up study, the frequency of respiratory infection every year of therapy group was significantly decreased than that of control group. CONCLUSION: Chinese materia medica could prevent infantile recurrent respiratory tract infection effectively, increase humoral immunity function and ensure normal growth in children.