| 活动期SLE患者血中ACTH、Cs、PRL变化的研究 |
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| 引用本文： | 王晓非,沈辉,张晓莉,柏树令. 活动期SLE患者血中ACTH、Cs、PRL变化的研究[J]. 中国医科大学学报, 2001, 30(2): 137-138,140 |
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| 作者姓名： | 王晓非 沈辉 张晓莉 柏树令 |
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| 作者单位： | 1. 中国医科大学第一临床学院免疫科,
2. 基础医学院解剖学教研室 |
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| 摘 要： | 目的：探讨系统性红斑狼疮（systemic lupus erythematosus,SLE）患 血中促肾上腺皮质激素（adrenocor-ticotropin,ACTH）、皮质醇（cortisol,Cs）、泌乳素(prolactin,PRL）的变化。方法：放免分析法。结果：活动期SLE患者血中ACTH，Cs高峰期分泌不足，PRL分泌增加，PRL／Cs比值增加，并与SLE疾病活动积分呈正相关。结论：内源性糖皮质激素的分泌不足及PRL的分泌增加，在SLE的发生发展中具有重要作用。
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| 关 键 词： | 系统性红斑狼疮 促肾上腺皮质激素 皮质醇 泌乳素 |
Changes of ACTH, Cs and PRL Levels in Peripheral Blood From Patients With Active Systemic Lupus Erythematosus |
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| WANG XiaoFei,Shen Hui,Zhang Xiaoli,Bai Shuling. Changes of ACTH, Cs and PRL Levels in Peripheral Blood From Patients With Active Systemic Lupus Erythematosus[J]. Journal of China Medical University, 2001, 30(2): 137-138,140 |
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| Authors: | WANG XiaoFei Shen Hui Zhang Xiaoli Bai Shuling |
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| Abstract: | Objective: Our purpose was to investigate the changes of adrenocorticotropin (ACTH), Cortisol (Cs) and prolactin (PRL) levels in peripheral blood of patients with active systemie lupus erythematosus(SLE). Methods: Radioimmunoassy. Results: Active SLE patients had a low level of ACTH,Cs in peak phase and a high level of PRL. Consequentaly, the ratio of PRL/Cs increased, which was positively correlative to active index of SLE. Conclusion: Endogenetic secretion in sufficiency of glucocorticalsteroid and increase of PRL have important function in the initiation and development of SLE. |
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| Keywords: | adrenocorticotropin cortisol prolactin systemic lupus erythematosus |
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