| 神经肽P物质、降钙素基因相关肽在膝骨性关节炎软骨下骨中的表达 |
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| 引用本文： | 付昌马,杨祖华.神经肽P物质、降钙素基因相关肽在膝骨性关节炎软骨下骨中的表达[J].中华临床医师杂志(电子版),2014(6):999-1003. |
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| 作者姓名： | 付昌马 杨祖华 |
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| 作者单位： | [1]安徽医科大学合肥第三临床学院,230022 [2]合肥市第三人民医院骨科,230022 |
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| 基金项目： | 安徽省合肥市科技局重点科研项目 |
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| 摘 要： | 目的研究证明含有神经肽P物质(SP)、降钙素基因相关肽(CGRP)共同存在于膝骨性关节炎(OA)中,本研究验证这些肽能神经在膝OA发病中可能起作用。探讨膝OA患者软骨下骨中神经肽SP、CGRP的表达及临床意义。方法收集2010年4月至2013年9月在合肥市第三人民医院治疗的40例膝OA患者及10例股骨下段骨折患者临床资料。免疫组化染色检测40例膝OA患者(OA组)及10例股骨下段骨折患者(正常对照组)软骨下骨组织神经肽SP、CGRP的阳性表达。结果 (1)40例膝OA患者与10例正常对照组比较,神经肽SP的阳性细胞表达数(2.62±0.31 vs.1.58±0.32,P<0.05)和神经肽CGRP的阳性细胞表达数(2.58±0.23 vs.1.55±0.25,P<0.05)均高于正常对照组。(2)40例膝OA患者与10例正常对照组比较,神经肽SP的平均光密度(0.345±0.031 vs.0.224±0.072,P<0.05)和神经肽CGRP的平均光密度(0.585±0.043 vs.0.326±0.065,P<0.05)均高于正常对照组。(3)40例膝OA患者神经肽CGRP的平均光密度(0.585±0.043)高于SP的平均光密度(0.345±0.031,P<0.05)。结论神经肽SP、CGRP在OA患者软骨下骨组织中水平显著增高;高表达的神经肽导致骨代谢失衡,膝关节内循环发生与调节紊乱,从而在膝OA发病中起重要作用。
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| 关 键 词： | 骨关节炎 膝 神经肽类 降钙素基因相关肽 P物质 |
Neuropeptides substance P and calcitonin gene related peptide expression in knee osteoarthritis subchondral bone |
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| Fu Changma,Yang Zuhua.Neuropeptides substance P and calcitonin gene related peptide expression in knee osteoarthritis subchondral bone[J].Chinese Journal of Clinicians(Electronic Version),2014(6):999-1003. |
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| Authors: | Fu Changma Yang Zuhua |
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| Institution: | . (Department of orthopedic, the Third Clinical College of Anhui Medical University, the Third People＇s Hospital of Hefei, Hefei 230022, China) |
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| Abstract: | Objective To study the expression of neuropeptide substance P （SP） and calcitonin gene related peptide （CGRP） in the subchondral bone patients with knee osteoarthritis （OA）. Methods A total 40 patients with OA were used as study group, and 10 patients with lower femur fractures were used as control group. Immunohistochemical staining were used to analyze neuropeptides SP and CGRP positive expression in 40 cases OA patients and 10 cases lower femur fractures patients. Results （1） The number of neuropeptide SP positive cells （2.62±0.31 vs. 1.58±0.32, P〈0.05） and neuropeptide CGRP positive cells （2.58±0.23 vs. 1.55±0.25, P〈0.05） was significantly higher in OA group than control group. （2） Neuropeptide SP average optical density（0.345±0.031 vs. 0.224±0.072, P〈0.05） and neuropeptide CGRP average optical density（0.585±0.043 vs. 0.326±0.065, P〈0.05） was significantly higher in OA group than control group. （3） Neuropeptide CGRP average optical density （0.585±0.043） was higher than the average optical density of SP （0.345±0.031） （P〈0.05） in OA group. Conclusion Significantly higher neuropeptide SP and CGRP levels were found in patients with OA;neuropeptide expression leading to bone metabolic imbalance, adjustment disorder with cycles occur within the joint, and thus play a role in OA group. |
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| Keywords: | Osteoarthritis knee Neuropeptides Calcitonin gene-related peptide Substance P |
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