脂联素与2型糖尿病大血管病变的相关研究

目的探讨血浆水平变化与2型糖尿病大血管病变的关系。方法80例研究对象设为正常对照组（NC）、糖尿病组（DM）及糖尿病大血管病变组（DM＋AS）。检测受试者颈动脉内膜中层厚度（IMT），然后与测定的血浆脂联素水平，白细胞计数（WBC）、空腹血糖（FBG）、空腹C肽（FCP）、糖化血红蛋白（HbAlc）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、收缩压（SBP）、舒张压（DBP）和体重指数（BMI）进行统计学分析。结果DM＋AS组的脂联素水平显著低于DM组和NC组；血清脂联素水平与SBP、DBP、BMI、FBG、HbAlc、TG、CIMT成负相关。结论2型糖尿病患者的血浆脂联素水平随着大血管病变的发生而降低，可用于预测动脉粥样硬化发生的危险性。

A study on adiponectin and type 2 diabetes mellitus with Macroangiopathy

Objective To explore the correlation between plasma adiponectin and type 2 diabetic patients with macroangiopathy. Methods 80 cases were divided into healthy control group（NC） , type 2 diabetes mellitus group（DM） and type 2 diabetes mellitus with macroangiopathy group（ DM ＋ AS）. The carotid intima - media thickness（CIMT） of subjects were determined. Meanwhile the plasma adiponectin levels, fasting blood glucose（FBG） ,fasting C - peptide（FCP）, glycated haemoglobin Alc （ HbAlc ） , total cholesterol （ TC ） , triglyceride （TG） , high density lipoproteincholesterol （ HDL - C ）, low density lipuprotein cholesterol（ LDL- C）, body mass index（BMI）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） measured in subjects were analysed with statistical methods. Results The levels of adiponectin in DM ＋ AS is the lowest in these groups. There was negatively correlation in levels of adiponectin and these items including SBP, BMI, FBG, HbAlc, TG, IMT. Conclusion A decreased plasma adiponectin level can be associated with the prevalence of type 2 diabetes mellitus with macroangiopathy