手术联合放化疗治疗儿童髓母细胞瘤的疗效分析

目的 探讨手术联合放化疗治疗儿童髓母细胞瘤（MB）的疗效。方法 回顾性分析2017年1月至2020年7月收治的32例儿童MB的临床资料。均采用枕下后正中入路手术切除肿瘤，术后行放化疗。结果 肿瘤完全或近完全切除26例，次全切除6例。术后发生小脑缄默症7例，硬膜外血肿1例，后组颅神经受损5例，皮下积液3例。32例随访止2020年12月，随访时间9～38个月，平均23.9个月，次全切除6例出现进展，其中脊髓转移3例，死亡5例；存活27例中，26例正常生活，1例因肿瘤进展需要照顾。结论 对于儿童MB，手术联合术后足疗程、足量放化疗，延缓肿瘤复发，提高生存率。

Clinical efficacy of surgical treatment combined with radiotherapy and chemotherapy for pediatric patients with medulloblastoma

Objective To investigate the clinical efficacy of surgical treatment combined with radiotherapy and chemotherapyforthe pediatric patients with medulloblastoma. Methods The clinical data of 32 children with medulloblastoma who received microsurgery combined with radiotherapy and chemotherapy from January 2017 to July 2020 were retrospectively analyzed. Results Total resection of tumors were achieved in 26 children and subtotal in 6. Cerebellar mutism occurred in 7 children, posterior cranialnerve damage in 5, subcutaneous effusion in 3 and epidural hematoma in 1 after the operation. The follow-up (range, 9~38 months;average, 23.9 months) showed progression in 6 children with subtotal resection, including 3 spinal cord metastasis and 5 death. Of 27survival children, 26 lived normally, and 1 required care due to tumor progression. Conclusions For children with MB, surgerycombined with a full course and adequate radiotherapy and chemotherapy can reduce tumor recurrence and improve the survival rate.