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Decline in national tuberculosis notifications with national scale-up of antiretroviral therapy in Malawi
Authors:H. Kanyerere  A. Mganga  A. D. Harries  K. Tayler-Smith  A. Jahn  F. M. Chimbwandira  J. Mpunga
Abstract:From 2000 to 2012, Malawi scaled up antiretroviral therapy (ART) from <3000 to 404 905 persons living with HIV/AIDS (human immunodeficiency virus/acquired immune-deficiency syndrome), representing an ART coverage of 40.6% among those living with HIV. During this time, annual tuberculosis (TB) notifications declined by 28%, from 28 234 to 20 463. Percentage declines in annual TB case notifications were as follows: new TB (26%), recurrent TB (40%), new smear-positive pulmonary TB (19%), new smear-negative pulmonary TB (42%), extra-pulmonary TB (19%), HIV-positive TB (30%) and HIV-negative TB (10%). The decline in TB notifications is associated with ART scale-up, supporting its value in controlling TB in high HIV prevalence areas in sub-Saharan Africa.
Keywords:ART   TB   Malawi   HIV/AIDS   recurrent TB
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