| 肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展 |
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| 引用本文： | 刘娟丽,马四清,陈强. 肺表面活性蛋白-D功能及其在肺部常见疾病中的研究进展[J]. 中华重症医学电子杂志, 2022, 8(2): 167-172. DOI: 10.3877/cma.j.issn.2096-1537.2022.02.013 |
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| 作者姓名： | 刘娟丽 马四清 陈强 |
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| 作者单位： | 1. 810007 西宁，青海省人民医院重症医学科；810001 西宁，青海大学高原医学研究中心2. 810007 西宁，青海省人民医院重症医学科 |
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| 基金项目： | 国家自然科学基金项目(81860351); 青海省高原重症医学重点实验室项目(2020-81); 青海省高原医学应用基础重点实验室（青海-犹他高原医学联合重点实验室）项目(2022-ZJ-Y15) |
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| 摘 要： | 肺表面活性蛋白-D（SP-D）是凝集素家族糖蛋白，主要在肺部的肺泡Ⅱ型上皮细胞和无纤毛细支气管上皮细胞合成和分泌，储存在Clara细胞的分泌颗粒中。SP-D是表面结合蛋白之一，也是组成肺表面活性系统的一部分。SP-D除了有助于肺泡空间内表面活性剂池稳态外，还具有宿主防御和免疫调节功能。本文通过对近年来SP-D在肺部常见疾病中的部分相关研究进行总结，为众多肺部疾病，特别是肺部炎症性疾病潜在的治疗提供重要的方法理论基础。
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| 关 键 词： | 表面活性蛋白-D 表面活性剂池稳态 宿主防御 免疫调节 |
| 收稿时间： | 2022-02-16 |
Research progress on the function of surfactant protein -D and its role in the common lung diseases |
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| Juanli Liu,Siqing Ma,Qiang Chen. Research progress on the function of surfactant protein -D and its role in the common lung diseases[J]. Chinese Journal of Critical Care & Intensive Care Medicine(Electronic Edition), 2022, 8(2): 167-172. DOI: 10.3877/cma.j.issn.2096-1537.2022.02.013 |
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| Authors: | Juanli Liu Siqing Ma Qiang Chen |
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| Affiliation: | 1. Department of Critical Care Medicine, Qinghai Provincial People′s Hospital, Xining 810007, China; Plateau Medical Center of Qinghai University, Xining 810001, China2. Department of Critical Care Medicine, Qinghai Provincial People′s Hospital, Xining 810007, China |
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| Abstract: | Lung surfactant protein D (SP-D) is a glycoprotein of the lectin family. In lungs it is synthesized and secreted mainly in the alveolar type Ⅱ epithelial cells and non-ciliated bronchiole epithelial cells, and are stored in secretory granules of Clara cells. SP-D is one of the surfactant binding proteins and is also a part of the pulmonary surfactant system. In addition to contributing to the homeostasis of surfactant pools in alveolar space, SP-D also exhibits functions of host defense and immunoregulation. This paper summarizes some relevant studies on SP-D in acute lung diseases in recent years, providing important theoretical basis for the potential treatment of many lung diseases, especially in inflammatory lung diseases. |
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| Keywords: | Surfactant proteins D Homeostasis of surfactant pools Host defense Immune regulation |
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