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Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients
Affiliation:1. INSERM U1052-Cancer Research Center of Lyon (CRCL), 69008 Lyon, France;2. University of Lyon, UMR_S1052, CRCL, 69008 Lyon, France;3. Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, France;4. Department of Virology, Croix Rousse Hospital, Hospices Civils de Lyon, France;5. Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy;6. Department of Internal Medicine – DMISM and the IIT Center for Life Nanoscience (CLNS), Sapienza University, Rome, Italy;1. Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China;2. The First Hospital of Guangxi Medical University, Nanning, Guangxi, China;3. Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin Province, China;1. Department of Medicine, The University of Hong Kong, Hong Kong;2. State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong;3. Department of Pathology, The University of Hong Kong, Hong Kong;4. Johns Hopkins University School of Medicine, MD, USA;5. Department of Medicine, Columbia University Medical Campus, New York City, NY, USA;1. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany;2. Department of Medicine and Therapeutics, Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong;3. Victorian Infectious Diseases Reference Laboratory (VIDRL), Doherty Institute for Infection and Immunity, Melbourne, Australia;4. Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Center of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, Italy;5. Toronto Center for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada;1. I. Dept. of Internal Medicine, Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2. German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel site, Germany;3. Institute of Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;1. Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Melbourne, Australia;2. Peter Doherty Institute of Infection and Immunity, Melbourne, Australia;3. Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA, USA;4. Hepatitis B Foundation, Doylestown, PA, USA;5. I Medical Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;6. German Centre for Infection Research (DZIF), Hamburg-Lübeck-Borstel partner site, Hamburg, Germany;7. Toronto General Hospital Research Institute, Department of Immunology, University of Toronto, Canada;8. Toronto Centre for Liver Disease, University of Toronto, Canada;9. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA;10. Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, USA;11. Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, School of Clinical Medicine, University of the Witwatersrand, Johannesburg, South Africa;12. CRC “A. M. and A. Migliavacca” Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy;13. INSERM Unit 1052, Cancer Research Center of Lyon, Lyon, France;14. Hepatology Department, Hospices Civils de Lyon, Lyon, France;15. Department of Internal Medicine - DMISM, Sapienza University, Rome, Italy;p. CLNS@SAPIENZA, Istituto Italiano di Tecnologia (IIT), Rome, Italy;q. National Institute of Biological Sciences, Beijing, China;r. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China;s. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA;t. Division of Gastroenterology and Hepatology, Department of Medicine, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore;u. Peking University Health Science Center, Beijing, China;v. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St Louis, MI, USA;w. Department of Medicine II, Medical Center, University of Freiburg, Freiburg, Germany;1. Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Canada;2. Division of Gastroenterology/Hepatology, University of California San Francisco, San Francisco, California
Abstract:
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  • Keywords:Hepatitis B virus (HBV)  Chronic hepatitis B (CHB)  Biomarker  Patient management  Pregenomic RNA (pgRNA)  Covalently closed circular DNA (cccDNA)
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