脑膜瘤Nestin表达与术后复发的关系

目的 探讨巢蛋白（Nestin）在脑膜瘤中的表达情况，分析其与脑膜瘤术后复发的关系。方法 收集2015年9月～2017年9月手术切除的169例脑膜瘤的肿瘤标本，采用免疫组化染色法检测肿瘤组织Nestin的表达水平。术后随访4年，采用多因素logistic回归模型分析脑膜瘤术后复发的危险因素。结果 169例中，术后复发43例，复发率为25.44%。169例脑膜瘤Nestin阳性表达率为73.37%(124/169)，其中WHO分级Ⅰ级脑膜瘤Nestin阳性表达率[50.94%(27/53)]明显低于Ⅱ级、Ⅲ级脑膜瘤[分别为80.90%(72/89)、92.59%(25/27);P<0.001]。多因素logistic回归分析显示，Nestin表达阳性是脑膜瘤术后复发的独立危险因素（P<0.05）。结论 脑膜瘤Nestin表达与肿瘤WHO分级有关，检测Nestin表达可用于评估脑膜瘤术后复发的风险。

Nestin expression in meningioma tissues and its clinical significance

Objective To investigate the expression of Nestin in meningioma tissues and analyze its relationship with postoperative recurrence. Methods The Nestin expression was detected using immunohistochemical method in meningioma tissues obtained from 169 patients with meningioma who underwent surgery from September 2015 to September 2017. All the patients were followed up for 4 years to analyze postoperative recurrence. Multivariate logistic regression was used to analyze the risk factors of postoperative recurrence. Results Of 169 patients with meningioma, 43 patients recurred and the postoperative recurrence rate was 25.44%. The positive rate of Nestin expression in WHO grade Ⅰ meningioma tissues (50.94%, 27/53) was significantly lower than those in WHO grade Ⅱ (80.90%, 72/89) and grade Ⅲ (92.59%, 25/27) meningioma tissues (P<0.05). Multivariate logistic regression analysis showed that Nestin positive expression was an independent risk factor for postoperative recurrence of meningioma (P<0.05). Conclusions The expression of Nestin in meningioma tissues is related to the WHO grade of meningioma. Detection of Nestin expression can be used to evaluate the risk of meningioma recurrence after surgery.