Venous thromboembolism as a cause of severe maternal morbidity and mortality in the United States |
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| Institution: | 1. Division of Blood Disorders, National Center on Birth Defects and Development Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA;2. Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA;1. The Stavros Niarchos Foundation-Collaborative Center for Clinical Epidemiology and Outcomes Research, National and Kapodistrian University of Athens School of Medicine, Athens, Greece;2. Department of Health Services Organization and Management, National School of Public Health, Athens, Greece;3. Corporate Affairs & Market Access, LEO Pharmaceutical Products Hellas S.A., Athens, Greece;4. Patient Access, Global Patient Solutions Thrombosis, LEO Pharma A/S, Ballerup, Denmark;1. California Maternal Quality Care Collaborative Maternal Venous Thromboembolism Task Force, Kaiser Permanente Riverside Medical Center, Riverside, CA, USA;2. Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, PH 16-66, New York, NY 10032, USA |
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| Abstract: | In the U.S., deaths due to pulmonary embolism (PE) account for 9.2% of all pregnancy-related deaths or approximately 1.5 deaths per 100,000 live births. Maternal deaths and maternal morbidity due to PE are more common among women who deliver by cesarean section. In the past decade, the clinical community has increasingly adopted venous thromboembolism (VTE) guidelines and thromboprophylaxis recommendations for pregnant women. Although deep vein thrombosis rates have decreased during this time-period, PE rates have remained relatively unchanged in pregnancy hospitalizations and as a cause of maternal mortality. Changes in the health profile of women who become pregnant, particularly due to maternal age and co-morbidities, needs more attention to better understand the impact of VTE risk during pregnancy and the postpartum period. |
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