中国6省18~75岁人群高钙尿症检出情况及影响因素

  目的  了解中国6省18~75岁人群高钙尿症检出情况及影响因素。为预防高钙尿症及其引发的其他疾病提供依据。  方法  采用多阶段整群随机抽样方法，抽取中国6省18~75岁2 693名调查对象，开展问卷调查、体格检查并收集24 h尿标本，检测24小时尿钙水平(24-hours urinary calcium, 24HUC)。  结果  最终纳入分析2 637名研究对象，共检出高钙尿症者258名，高钙尿症检出率为9.78%，其中男性和女性高钙尿症检出率分别是8.47%和11.09%(χ2 =5.124, P=0.024)。多因素Logistic回归分析模型分析显示，女性(OR=1.366, 95% CI: 1.051~1.778, P=0.020)、45~＜60岁(OR=2.069, 95% CI: 1.404~3.049, P < 0.001)、超重(OR=1.661, 95% CI: 1.216~2.268, P=0.001)、肥胖(OR=2.623, 95% CI: 1.855~3.709, P < 0.001)及患糖尿病(OR=1.988, 95% CI: 1.292~3.060, P=0.002)与高钙尿症的发生相关。  结论  中国人群高钙尿症检出率较高，建议重点人群应开展24HUC的筛查工作，及早预防高钙尿症及其引发的其他疾病。

The detection of hypercalciuria and influencing factors among people aged 18-75 years old in six provinces of China

  Objective  To investigate the detection of hypercalciuria and influencing factors among people aged 18-75 years old in six Provinces of China, and to provide basis for prevention of hypercalciuria and other diseases.  Methods  A total of 2 693 subjects aged 18-75 years old were selected from 6 provinces in China. Using multi-stage cluster random sampling method. Information were collected through questionnaire survey, physical measurement and 24-hours urine collection (24HUC). The 24-hours urinary calcium level was measured.  Results  A total of 2 637 subjects were included in the final analysis, of which 258 subjects were detected with hypercalciuria, and the detection rate was 9.78%. The male and female hypercalciuria detection rates were 8.47% and 11.09%, respectively (χ2 =5.124, P=0.024). Multivariate Logistic regression analysis showed that female (OR=1.366, 95% CI: 1.051-1.778, P=0.020), people aged 45- < 60 years old (OR=2.069, 95% CI: 1.404-3.049, P < 0.001), overweight (OR=1.661, 95% CI: 1.216-2.268, P=0.001), obesity (OR=2.623, 95% CI: 1.855-3.709, P < 0.001), and people with diabetes mellitus (OR=1.988, 95% CI: 1.292-3.060, P=0.002) were related with hypercalciuria.  Conclusions  The detection rate of hypercalciuria in Chinese population is high. It is suggested that 24HUC screening should be carried out in target population to prevent hypercalciuria and other diseases as soon as possible.