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Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Institution:1. Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA;2. Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA;3. Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA;1. Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain;2. School of Medicine, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain;3. School of Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain;4. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA;5. Institute for Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA;6. Unidad Mixta CIPF-UCV, Centro de Investigación Príncipe Felipe, Valencia, Spain;1. Centre for Psychiatry, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom;2. East London Foundation NHS Trust, London, United Kingdom;3. Barts Health Trust, London, United Kingdom;1. School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia;2. Hunter Medical Research Institute, 1 Kookaburra Circuit, New Lambton, NSW, 2305, Australia;3. The Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins University School of Medicine, Baltimore, MD, USA;4. F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore MD, USA;5. Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia;6. Department of Neurology, John Hunter Hospital, New Lambton Heights, Newcastle, 2305, Australia;7. School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, 2308, Australia;1. Department of Rheumatology Research, Division of Medicine, University College of London, Rayne Building, 5, University Street, WC1E 6JF London, United Kingdom;2. Department of Immunology, Epsom and St-Helier University Hospitals NHS Trust, London, United Kingdom
Abstract:
Keywords:deoxyuridine triphosphate nucleotidohydrolase (dUTPase)  Epstein-Barr virus (EBV)  myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)  synaptic plasticity  Toll-like receptor 2 (TLR2)
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