| 全球结核分枝杆菌谱系分布与耐药分析 |
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| 引用本文： | 王钰婷, 陶必林, 李忠奇, 吴继周, 丁洁, 王建明. 全球结核分枝杆菌谱系分布与耐药分析[J]. 中华疾病控制杂志, 2022, 26(11): 1248-1251. doi: 10.16462/j.cnki.zhjbkz.2022.11.002 |
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| 作者姓名： | 王钰婷 陶必林 李忠奇 吴继周 丁洁 王建明 |
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| 作者单位： | 1.211166 南京，南京医科大学公共卫生学院全球健康中心流行病学系;;2.210003 南京，南京医科大学附属南京疾病预防控制中心慢性传染病防制科 |
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| 基金项目： | 国家自然科学基金81973103江苏卫生健康委医学科研项目ZDB2020013南京市重大科技专项2021-11005 |
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| 摘 要： | 目的 绘制全球结核分枝杆菌复合群(Mycobacterium tuberculosis complex, MTBC)地理分布图，描述不同地区的MTBC主要谱系分布及耐药情况。方法 利用TB-Profiler平台MTBC全基因组测序数据和耐药检测结果，绘制全球MTBC谱系分布图，并根据不同地域、亚谱系的层次结构进行可视化分析。结果 Lineage 4谱系在全球分布最广，Lineage 2谱系耐药发生率最高。结论 世界范围内MTBC谱系的地理分布及不同谱系间耐药情况存在差异。
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| 关 键 词： | 结核病 全基因组测序 结核分枝杆菌复合群 谱系 |
| 收稿时间： | 2022-03-28 |
| 修稿时间： | 2022-06-12 |
Global geographical pedigree distribution and drug resistance of Mycobacterium tuberculosis complex |
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| WANG Yu-ting, TAO Bi-lin, LI Zhong-qi, WU Ji-zhou, DING Jie, WANG Jian-ming. Global geographical pedigree distribution and drug resistance of Mycobacterium tuberculosis complex[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(11): 1248-1251. doi: 10.16462/j.cnki.zhjbkz.2022.11.002 |
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| Authors: | WANG Yu-ting TAO Bi-lin LI Zhong-qi WU Ji-zhou DING Jie WANG Jian-ming |
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| Affiliation: | 1. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China;;2. Department of Chronic Infectious Disease Prevention and Control, Nanjing Center for Disease Control and Prevention Affiliated to Nanjing Medical University, Nanjing 210003, China |
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| Abstract: | Objective To map the global geographical distribution of Mycobacterium tuberculosis complex (MTBC) and describe the main MTBC lineage and drug resistance in different regions. Methods We used the whole-genome sequencing data from the TB-profiler platform to plot the global MTBC distribution map and visualized it according to the hierarchical structure of different regions and sub-lineages. Results Lineage 4 was widely distributed worldwide, while lineage 2 had the highest risk of drug resistance. Conclusions There was a significantly different geographic distribution pattern and drug resistance of MTBC lineages worldwide. |
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| Keywords: | Tuberculosis Whole-genome sequencing Mycobacterium tuberculosis complex Lineage |
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