T cell epitopes of Per a 10 modulate local-systemic immune responses and airway inflammation by augmenting Th1 and T regulatory cell functions in murine model |
| |
| Affiliation: | 1. CSIR-Institute of Genomics and Integrative Biology, Mall road, Delhi, India;2. Academy of Scientific & Innovative Research (AcSIR), CSIR-IGIB, Delhi, India;1. Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil;2. Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil;1. Department of Immunology, Institute for Biological Research “Siniša Stanković”, University of Belgrade, Serbia;2. Immunology Division, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain;3. Department of Cellular Biology, Physiology, and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain;4. Laboratory for Plant Molecular Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia;5. Institute for Microbiology and Immunology, School of Medicine, University of Belgrade, Serbia;1. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran;4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;1. Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil;2. Fundação Oswaldo Cruz, Centro de Pesquisa Gonçalo Moniz, Salvador, Brazil;1. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China;2. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China;1. Cardiology Program, The Prince Charles Hospital, Rode Road, Chermside, Brisbane, QLD, Australia;2. University of Queensland, St Lucia, Brisbane, QLD, Australia |
| |
| Abstract: | Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolution of pathophysiological features such as reduced recruitment of inflammatory cells to airways, lowered specific IgE, induction of IgG2a antibodies in serum, immune deviation towards Th1 cytokine milieu, suppression of Th2 cytokines in BALF and splenocyte culture supernatant and resolution of lung inflammation. A significant increase in CD4+Foxp3+ cells in spleen indicate towards induction of T regulatory cell mediated peripheral tolerance characterized by shift in cytokine milieu from Th2 to T regulatory cytokines. PIT modulates regulation of immune responses at both local and systemic levels, contributes towards holistic improvement in allergic features in mice and thus demonstrate potential for safe, specific and efficacious treatment for cockroach allergy. |
| |
| Keywords: | Immunotherapy Airway inflammation Th2 response Immune deviation T cell tolerance |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
